A postdoctoral fellowship for 2 years is available as early as April 2021 at Institut Cochin. The Myestrom research project, funded by the ANR, and coordinated by Céline Méhats in collaboration with Anne Hosmalin, aims to further unravel the heterogeneity and functions of myeloid subpopulations at the maternal-fetal interface and unveil their dynamics during parturition.
Prematurity and its complications are the leading cause of death in children under the age of 5 years and can cause long-term health problems. Our goal is the identification of all cell types of the human and murine maternal-fetal interface, especially myeloid and stromal cells, and the characterization of their crosstalk and fate during labor, to better understand the molecular mechanisms responsible for labor onset. We will use cutting edge technologies, including multidimensional flow and spectral cytometry and single-nucleus RNA sequencing.
Institut Cochin provides a highly dynamic scientific life between fundamental and clinical research in the center of Paris (https://www.institutcochin.fr). The postdoctoral fellow will work in the group of Céline Méhats from the team “From Gametes to Birth”, DRC Department (Development, Reproduction, Cancer) and in the team of Anne Hosmalin, 3I Department (Infection, Immunity, Inflammation) and will benefit from the expertise of the other project partner Ludivine Doridot and of the state-of-the-art core facilities (Genomics, NGS, cytometry).
The successful post-doctoral fellow will perform detailed immunophenotyping of myeloid cells of maternal-fetal interface during late pregnancy.
The project will include a variety of ex vivo and in vitro approaches in human and mouse models.
The fellow is expected to interpret and criticize his/her own results as well as to write scientific articles and perform oral presentations in local, national and international meetings.
-PhD in Immunology
– Strong experience in Immunology and demonstrated skills in multidimensional flow cytometry, cell biology, including cell cultures, molecular biology is required.
– Experience in myeloid cell biology, mouse models, single-cell and bulk transcriptomics and genomics are a plus.
-Dedicated, highly self-motivated and innovative, autonomous and rigorous. Good communication skills that allow productive interactions with an interdisciplinary team (Bioinformatics and biology). Ability to communicate in both spoken and written English.
– Prior experience in the field of reproduction is not mandatory.