Application from January 2021 until candidate found. Position starting in February 2021.

 Applicants are invited for a 3-years position within the research group led by Dr. Olivier Lantz to work on Mucosal Associated Invariant T (MAIT) cells biology in the context of his ERC advanced (2020-2025). The project will address this topic and will be defined with the applicant according to his/her expertise and wishes.

The team studying MAIT cell biology encompasses 10 persons: 2 staff-scientists, 2 postdocs, 4 PhD students, and 2 technicians. The techniques used routinely are multicolor FACS analysis and sorting, quantitative PCR, transgenic and KO mice, cell transfection, NGS, cellular immunology.  Many studies will be done in vivo in mice.

The group is part of a 130-person immunology department headed by S. Amigorena. The lab is located within the Institut Curie campus in the center of Paris.  The building is equipped with state of the art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms). The Institute hosts around 1500 bench scientists including many foreign post-doctoral fellows. The candidate will benefit from a stimulating pluridisciplinary environment.

Candidates will have a Ph.D. in immunology. She/he should have demonstrated success in a previous research experience in immunology or related fields testified by publications. Strong motivation, autonomy and ability to quickly and effectively develop new projects in relation with the group leader and collaborators will be essential.

Written and spoken English is mandatory.

Informal enquiries can be made to Dr. Olivier Lantz by mail.

Please send CV, motivation letter and contact details of at least two persons able to provide references.

References

  1. F Legoux*, J. Gilet*, E. Procopio, K. Echasserieau, K. Bernardeau and O. Lantz. 2019. Molecular mechanisms of lineage decisions in metabolite-specific T cells. Nature Immunol. 20, 1244-1255.
  2. Legoux, D. Bellet, C. Daviaud, Y.El Morr, A. Darbois, K. Niort, E. Procopio, M. Salou, J. Gilet, B. Ryffel, A. Balvay, A. Foussier, M. Sarkis, A. El Marjou, F. Schmidt, S. Rabot and O. Lantz. 2019. Microbial metabolites control the thymic development of Mucosal Associated Invariant T cells. Science 366, 494-499.
  3. Salou, M.*, F. Legoux*, J. Gilet*, A. Darbois, A. du Halgouet, R. Alonso, W. Richer, A.G. Goubet, C. Daviaud, M. Menger, E. Procopio, V. Premel, and O. Lantz. A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets. J Exp Med Jan 7;216(1):133-151.
  4. Alonso*, H. Flament*, S. Lemoine*, C. Sedlik, E. Bottasso, V. Prémel, J. Denizeau, M. Salou, A. Darbois, N. G. Nunez, B. Salomon, D. Gross, E. Piaggio and O. Lantz. 2018. Lung tumors enforce the induction of anergic/regulatory tumor-specific CD4+ T cells in the tumor draining lymph node. Nature communications. 2113
  5. Cui*, K. Franciszkiewicz*, Y. Mburu, S. Mondot, V. Premel, E.Martin, A. Kachaner,L. Duban, M Ingersoll, S.Rabot, J. Jaubert, J.-P. De Villartay, C. Soudais, O. Lantz. 2015. Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation. JCI 125(11):4171-85.
  6. L Le Bourhis, E Martin, I Péguillet, A Guihot, N Froux, M Coré, E Levy, M Dusseaux, V Meyssonnier, V Premel, C Ngo, B Riteau, L Duban, D Robert, M Rottman, C Soudais, O Lantz. Anti-bacterial reactivity of Mucosal Associated Invariant T cells. Nature Immunology 11(8): 701.