A post-doctoral position for 3 years is available at the “Centre d’Immunologie de Marseille Luminy” (CIML, France) to work on thymic activity and T-cell immunity with a starting date in October/November 2020.
The successful candidate will work in the context of the ANR RANKLThym project led by Dr. Magali IRLA.
The thymus ensures a continuous production of T lymphocytes that are pivotal in the host defense against pathogens and malignant cells. This organ is highly sensitive to myeloablative regimen such as radiation and chemotherapy used to treat hematological disorders by hematopoietic stem cell transplantation (HSCT) or bone marrow transplantation (BMT). Furthermore, it undergoes profound alterations during the natural process of aging. Thymic damages engendered by both myeloablative regimen and aging result in an impaired T-cell production, which can lead to serious clinical complications such as opportunistic infections, autoimmunity or tumor relapse. Nevertheless, the thymus is prone to regenerative therapies. The identification of effective therapeutic molecules that boost the recovery of thymic activity constitutes an unmet clinical need that is expected to improve immunity and survival of numerous patients. In this context, our lab identified that the cytokine RANK ligand (RANKL) boosts thymic regeneration and T-cell production upon BMT (Lopes et al. EMBO Mol Med. 2017).
We are looking for a highly motivated candidate with a strong background in immunology and infection to study the potential of RANKL to restore effective immune functions upon BMT and aging. The successful candidate will join a dynamic and collaborative team with extensive scientific exchanges and will benefit from the excellent scientific environment of the CIML and its mouse, imaging and flow cytometry research facilities.
- PhD in immunology
- Good background in infection and immunology
- Strong expertise in multicolor flow cytometry
- Mouse handling
Highly motivated candidates should send an application containing a CV, a publication list, a brief statement of research accomplishment and career objective and the name of at least 2 referees to:
– Lopes N, Vachon H, Marie J and Irla M*. Administration of RANKL boosts thymic regeneration upon bone marrow transplantation. EMBO Mol Med. 2017 Jun;9(6):835-851. *Corresponding.
– Lopes N, Charaix J, Cédile O, Sergé A, Irla M*. Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells. Nat Commun. 2018 Mar 28;9(1):1262. *Corresponding.
– McCarron MJ#, Irla M#, Sergé A, Soudja SM, Marie JC. Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection. Nat Commun. 2019 Dec 19;10(1):5690. #Equal contribution.
– Lopes N, Sergé A, Ferrier P, Irla M*. Thymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance Induction. Front Immunol. 2015 Jul 20;6:365. *Corresponding.