The laboratory of Prof. Jens Stein at the Department of Oncology, Microbiology and Immunology (OMI) of the University of Fribourg/Switzerland is looking for a motivated and skilled candidate to join our team of 5-8 scientists who mainly work on distinct aspects of CD8+ T cell responses and their interactions with lymphoid and non-lymphoid tissue microenvironments. This process is essential for immune defense against viruses and other pathogens.

Adaptive immune reponses are initated in lymphoid tissue, which is now recognized to host additional areas beyond the well-described B cell follicles and T cell zones. In a thesis project in collaboration with the group of Prof. Christopher Mueller at the University of Strasbourg, France, we aim to understand the role of a little-studied lymphoid microenvironement enriched in innate immune cells and its impact on adaptive immune responses. From this analysis, we expect to uncover new links between structure and function of lymphoid microenvironments that govern the crosstalk between innate and adaptive immune systems during inflammation.

Requirements

  • Master in Science with strong motivation to work in immunology and imaging
  • Good work organization, curious, creative, goal-oriented

Techniques

Cutting edge celllular and molecular immunology technbiques, imaging, modern mouse genetics

We offer

  • Collaborative international research environment in a dynamic and competitive field
  • Regular courses and seminars by UNIFR Life Science Graduate school on-site and in neighboring Universities of Bern and Lausanne
  • Friendly and cooperative research team; English is main language

Selected references (*, corresponding authorship)

  1. Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance. Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser KA, Jafari SMS, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV*. Sci Immunol. 2020 Apr 3;5(46). pii: eaaz4371. doi: 10.1126/sciimmunol.aaz4371.
  2. The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ T cells. Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck R, Balmer J, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel M, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV*. 2018. J Exp Med (2018) 215:1869–1890. doi:10.1084/jem.20170896.
  3. Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. Hons M*, Kopf A, Hauschild R, Leithner A, Gärtner F, Abe J, Renkawitz J, Stein JV*, Sixt M*. Nat Immunol. Jun;19(6):606-616. doi: 10.1038/s41590-018-0109-z.
  4. pMHC affinity controls duration of CD8+ T cell – DC interactions and imprints timing of effector differentiation versus expansion. Ozga AJ, Moalli, F, Swoger J, Abe J, Sharpe J, Zehn D, Ripoll J, Stein JV*. 2016. J Exp Med. 2016 Nov 14;213(12):2811-2829

 

Lab website: https://www3.unifr.ch/med/de/research/groups/stein/

Applications to Prof. Jens Stein (jens.stein@unifr.ch)