Work environment:
One postdoctoral research fellow position is open in the newly created ATIP Avenir team led by Alexandre Paccalet, within the CarMeN lab (cardiovascular, metabolism, and nutrition) in Lyon, France. Our group investigates how immune cell metabolism drives inflammatory and tissue remodeling processes in cardiovascular diseases, including myocardial infarction, stroke, myocarditis, and heart failure, combining fundamental, translational, and clinical approaches. The group works within the CarMeN lab infrastructure and collaborates with its researchers and clinical partners, benefiting from cutting-edge platforms
Project:
The project addresses the metabolic adaptations in myeloid progenitors and circulating monocytes following acute myocardial infarction (MI). Building on evidence of metabolic switches in these cells, we aim to map metabolic shifts over time, examining how glucose and fatty acid metabolism fluctuate post-MI. We hypothesize that targeting metabolic pathways in a time-sensitive manner could reduce monocyte-driven inflammation and potentially improve cardiac recovery. Using established human cohorts and mouse models, this work aims to elucidate the metabolic evolution in myeloid cells post-MI, identifying biomarkers and therapeutic targets to reduce CVD-related inflammation without compromising immune defense.
To address these questions, we will combine state-of-the-art single-cell transcriptomics, multiparametric flow cytometry, mass spectrometry, and imaging approaches to analyze the heterogeneity and functions of monocytes in wild-type and transgenic mouse models, and in human cohorts.
