Webinars of the Vaccinology Club of the French Society of Immunology
TRAINED IMMUNITY AND VACCINATION
Organizers:
Dr Anne
Sophie Beignon (CEA)
Pr Lelievre Jean-Daniel (VRI)
Background :
Trained immunity is a state of the innate immune response associated with long-term epigenetic reprogramming of innate immune cells. This concept originated in the field of infectious diseases and vaccination.
In the field of vaccination, epidemiological data suggested that vaccination with live attenuated vaccines, and BCG in particular, had a beneficial impact on the occurrence of infections with different pathogens.
Studies carried out to understand this effect have shown that, following such vaccinations, an epigenetic reprogramming of innate immune cells, such as monocytes, macrophages and/or natural killer cells (known as trained peripheral immunity), can be observed. It has been shown that this reprogramming can also be observed in immune progenitor cells in the bone marrow (i.e. trained central immunity).
Webinars
The French Society of Immunology’s Vaccinology Club is organizing 3 webinars to provide a better understanding of this subject and its potential impact/interest in vaccination. The different webinars will focus on
1) Molecular mechanisms of Trained immunity
2) Central training of HSPCs and local training of tissue-resident innate cells
3) Trained immunity in clinical practice
