Ce mois-ci, la SFI et le Club Français des Jeunes Immunologistes mettent en avant l’article publié dans Scientific Reports, de Guilhem Lalle, qui fait sa thèse avec le Dr. Yenkel Grinberg-Bleyer, au Centre de Recherche en Cancérologie de Lyon (CRCL). L’article sera publié sur le site de la SFI durant tout le mois de Juin et concourra pour le prix du  » Meilleur article doctorant » au mois d’octobre prochain.

 

Journal Scientific Reports
Titre A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
Auteurs Guilhem Lalle, Raphaëlle Lautraite, Allison Voisin, Julie Twardowski, Pierre Stéphan, Marlène Perrin‑Niquet, Ramdane Igalouzene, Saidi M. Soudja, Julien C. Marie, Marc Vocanson, Nilushi De Silva, Ulf Klein, Sankar Ghosh & Yenkel Grinberg‑Bleyer
Résumé NF-kappaB (NF-κB) is a family of transcription factors with pleiotropic functions in immune responses. The alternative NF-κB pathway that leads to the activation of RelB and NF-κB2, was previously associated with the activation and function of T cells, though the exact contribution of these NF-κB subunits remains unclear. Here, using mice carrying conditional ablation of RelB in T cells, we evaluated its role in the development of conventional CD4+ T (Tconv) cells and their function in autoimmune diseases. RelB was largely dispensable for Tconv cell homeostasis, activation and proliferation, and for their polarization toward diferent favors of Thelper cells in vitro. Moreover, ablation of RelB had no impact on the capacity of Tconv cells to induce autoimmune colitis. Conversely, clinical severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS) was signifcantly reduced in mice with RelB-defcient T cells. This was associated with impaired expression of granulocyte–macrophage colony-stimulating factor (GM-CSF) specifcally in the central nervous system. Our data reveal a discrete role for RelB in the pathogenic function of Tconv cells during EAE, and highlight this transcription factor as a putative therapeutic target in MS.
A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis | Scientific Reports (nature.com)