The lab
Our group focuses on fundamental aspects of host-pathogen interactions and particularly on the innate immune implications of cellular metabolism and mitochondrial reprogramming. We study how innate immune signals are translated into metabolic adaptations and how genetic mutations affecting mitochondria-associated genes impact immunity. The institute is located in a brand-new building of a campus that gathers the university of Bordeaux the University-Hospital and worldwide renown research institutes (IINS, Magendie institute, MFP, IBGC) in the heart of Bordeaux. We offer excellent scientific training and mentorship, international collaborations and a team-oriented productive work environment.
The project
The current project focuses on the innate immune functions of the mitochondrial respiratory chain and mitochondrial metabolism in macrophages. It will involve a number of experimental techniques including mouse models of bacterial infection and functional characterization of primary murine and human cells. Approaches in the lab involve standard immunological, cell biology and biochemical techniques (immunoblotting, ELISA, ELISPOT, reporter assays, microscopy, oxygraphy) as well as metabolomics and NGS approaches.
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