Céline DELALOY

Céline Delaloy obtained her PhD in Human genetics from UPMC in 2006. Her basic research efforts are focused on characterizing the molecular and cellular processes controlling gene expression and cell fate determination in pathophysiological models. After completing a postdoctoral training in Gladstone Institutes, University of California San Francisco, where she studied epigenetic mechanisms involved in neuronal differentiation, she was recruited by INSERM in 2013. In the U1236 lab, she explores signal integration and B cell responses to external cues directing plasma cell differentiation using experimental models and single cell approaches. Terminal differentiation of B lymphocytes into plasma cells is finely controlled in time and space in response to signals from the microenvironment. The disruption of the signaling pathways that control this process is at the origin of autoimmune diseases and lymphomas. IL-2 is one of the first cytokine discovered but its complex roles on T cell effector functions has shadowed its function on B cell responses. Her research focuses on the roles of IL-2<BACH2 axis.